Version 5.4
Homo sapiens Protein: KIAA1324
Summary
InnateDB Protein IDBP-100785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KIAA1324
Protein Name KIAA1324
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358955
InnateDB Gene IDBG-100781 (KIAA1324)
Protein Structure
UniProt Annotation
Function May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. {ECO:0000269PubMed:21072319}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269PubMed:21072319}. Late endosome membrane {ECO:0000269PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269PubMed:21072319}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269PubMed:21072319}. Lysosome membrane {ECO:0000269PubMed:21072319}; Single-pass membrane protein {ECO:0000269PubMed:21072319}.
Disease Associations
Tissue Specificity Expressed in normal endometrium but overexpressed in endometroid tumors. {ECO:0000269PubMed:16322283}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0044822 poly(A) RNA binding
Biological Process
GO:0009267 cellular response to starvation
GO:0016236 macroautophagy
GO:0044090 positive regulation of vacuole organization
GO:2000786 positive regulation of autophagic vacuole assembly
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005802 trans-Golgi network
GO:0005887 integral component of plasma membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR009011 Mannose-6-phosphate receptor binding domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UXG2
PhosphoSite PhosphoSite-Q6UXG2
TrEMBL E9PS21
UniProt Splice Variant
Entrez Gene 57535
UniGene Hs.739368
RefSeq NP_065826
HUGO HGNC:29618
OMIM 611298
CCDS CCDS794
HPRD 13850
IMGT
EMBL AB037745 AL138933 AL356389 AY358366 BC125208
GenPept AAI25209 AAQ88732 BAA92562 CAI13596 CAI13597 CAI13598 CAI22280

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca