Homo sapiens Protein: AMIGO1
Summary
InnateDB Protein IDBP-100841.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AMIGO1
Protein Name adhesion molecule with Ig-like domain 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000358880
InnateDB Gene IDBG-100839 (AMIGO1)
Protein Structure
UniProt Annotation
Function Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity). {ECO:0000250UniProtKB:Q80ZD7}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=Associated with axons of neuronal cells. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007409 axonogenesis
GO:0007413 axonal fasciculation
GO:0042552 myelination
GO:0050772 positive regulation of axonogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030424 axon
Protein Structure and Domains
PDB ID
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
PFAM PF01463
PF00560
PF13504
PF13855
PF07679
PF07686
PRINTS
PIRSF
SMART SM00082
SM00369
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86WK6
PhosphoSite PhosphoSite-Q86WK6
TrEMBL
UniProt Splice Variant
Entrez Gene 57463
UniGene Hs.726479
RefSeq
HUGO HGNC:20824
OMIM 615689
CCDS CCDS30795
HPRD 11129
IMGT
EMBL AB032989 AK295678 AL355145 AY237007 BC040879
GenPept AAH40879 AAO48948 BAA86477 BAG58535 CAI22942