InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNA2

Summary

InnateDB Protein

IDBP-100994.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNA2

Protein Name

potassium voltage-gated channel, shaker-related subfamily, member 2

Synonyms

HBK5; HK4; HUKIV; KV1.2; MK2; NGK1; RBK2;

Species

Homo sapiens

Ensembl Protein

ENSP00000358785

InnateDB Gene

IDBG-100992 (KCNA2)

Protein Structure

UniProt Annotation

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0044224	juxtaparanode region of axon

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003972 Potassium channel, voltage dependent, Kv1
IPR004049 Potassium channel, voltage dependent, Kv1.2
IPR004050 Potassium channel, voltage dependent, Kv1.3
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold

PFAM

PF02214
PF00520

PRINTS

PR00169
PR01496
PR01509
PR01510

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt