Version 5.4
Homo sapiens Protein: DRAM2
Summary
InnateDB Protein IDBP-101014.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DRAM2
Protein Name DNA-damage regulated autophagy modulator 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000286692
InnateDB Gene IDBG-101012 (DRAM2)
Protein Structure
UniProt Annotation
Function Induces apoptotic cell death when coexpressed with DRAM1. {ECO:0000269PubMed:19895784}.
Subcellular Localization Lysosome membrane {ECO:0000269PubMed:19556885, ECO:0000269PubMed:19895784}; Multi- pass membrane protein {ECO:0000269PubMed:19556885, ECO:0000269PubMed:19895784}.
Disease Associations
Tissue Specificity Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Not detected in brain or thymus. {ECO:0000269PubMed:19556885, ECO:0000269PubMed:19895784}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0030262 apoptotic nuclear changes
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0015630 microtubule cytoskeleton
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR019402 Frag1/DRAM/Sfk1
PFAM PF10277
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6UX65
PhosphoSite PhosphoSite-Q6UX65
TrEMBL S4R2Z2
UniProt Splice Variant
Entrez Gene 128338
UniGene
RefSeq XP_005270526
HUGO HGNC:28769
OMIM 613360
CCDS CCDS30801
HPRD 14685
IMGT
EMBL AK075350 AL355816 AY336747 AY358492 BC047025 BC091509 CH471122 EF710624
GenPept AAH47025 AAH91509 AAQ88856 AAR02410 ABR27678 BAC11562 CAI19366 EAW56464 EAW56467 EAW56468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca