InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHIA

Summary

InnateDB Protein

IDBP-101039.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHIA

Protein Name

chitinase, acidic

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358755

InnateDB Gene

IDBG-101035 (CHIA)

Protein Structure

UniProt Annotation

Function

Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. {ECO:0000269PubMed:11085997, ECO:0000269PubMed:18824549, ECO:0000269PubMed:19342690, ECO:0000269PubMed:19435888}.

Subcellular Localization

Isoform 1: Secreted. Note=Secretion depends on EGFR activity.Isoform 2: Cytoplasm.Isoform 3: Cytoplasm.

Disease Associations

Tissue Specificity

Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung. {ECO:0000269PubMed:11085997, ECO:0000269PubMed:15192232}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003796	lysozyme activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568	chitinase activity
GO:0008061	chitin binding
GO:0019900	kinase binding
GO:0030246	carbohydrate binding

Biological Process

GO:0000272	polysaccharide catabolic process
GO:0001101	response to acid
GO:0002532	production of molecular mediator involved in inflammatory response
GO:0005975	carbohydrate metabolic process
GO:0006030	chitin metabolic process
GO:0006032	chitin catabolic process
GO:0006037	cell wall chitin metabolic process
GO:0006915	apoptotic process
GO:0006955	immune response
GO:0007586	digestion
GO:0009620	response to fungus
GO:0090197	positive regulation of chemokine secretion

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001223 Glycoside hydrolase, family 18, catalytic domain
IPR002557 Chitin binding domain
IPR011583 Chitinase II
IPR017853 Glycoside hydrolase, superfamily
IPR029070 Chitinase insertion domain

PFAM

PF00704
PF01607

PRINTS

PIRSF

SMART

SM00494
SM00636

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9BZP6