InnateDB Protein
|
IDBP-101281.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SYT6
|
Protein Name
|
synaptotagmin VI
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000358560
|
InnateDB Gene
|
IDBG-101279 (SYT6)
|
Protein Structure
|
|
Function |
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.Isoform 1: Membrane {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Note=Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment. {ECO:0000250}.Isoform 2: Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
2 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000008
C2 domain
IPR001565
Synaptotagmin
|
PFAM |
PF00168
|
PRINTS |
PR00360
PR00399
|
PIRSF |
|
SMART |
SM00239
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q5T7P8
|
PhosphoSite |
PhosphoSite-Q5T7P8
|
TrEMBL |
V9GYY7
|
UniProt Splice Variant |
|
Entrez Gene |
148281
|
UniGene |
Hs.733656
|
RefSeq |
NP_001257734
|
HUGO |
HGNC:18638
|
OMIM |
607718
|
CCDS |
CCDS871
|
HPRD |
09654
|
IMGT |
|
EMBL |
AK056448
AL162594
BC044948
CH471122
|
GenPept |
AAH44948
BAG51713
CAI18964
CAM27152
EAW56596
EAW56597
|
|
|