Version 5.4
Homo sapiens Protein: SIKE1
Summary
InnateDB Protein IDBP-101325.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIKE1
Protein Name suppressor of IKBKE 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000060969
InnateDB Gene IDBG-101319 (SIKE1)
Protein Structure
UniProt Annotation
Function Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways. {ECO:0000269PubMed:16281057}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16281057}.
Disease Associations
Tissue Specificity Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level). {ECO:0000269PubMed:16281057}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR008555 Suppressor of IKBKE 1
PFAM PF05769
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRV8
PhosphoSite PhosphoSite-Q9BRV8
TrEMBL
UniProt Splice Variant
Entrez Gene 80143
UniGene Hs.709277
RefSeq NP_079349
HUGO HGNC:26119
OMIM 611656
CCDS CCDS878
HPRD 07958
IMGT
EMBL AK024821 AL096773 BC005934 CH471122 CR749219
GenPept AAH05934 BAB15020 CAH18076 CAI18822 CAI18823 CAI18824 EAW56620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca