InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NGF

Summary

InnateDB Protein

IDBP-101349.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NGF

Protein Name

nerve growth factor (beta polypeptide)

Synonyms

Beta-NGF; HSAN5; NGFB;

Species

Homo sapiens

Ensembl Protein

ENSP00000358525

InnateDB Gene

IDBG-101347 (NGF)

Protein Structure

UniProt Annotation

Function

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.

Subcellular Localization

Secreted.

Disease Associations

Neuropathy, hereditary sensory and autonomic, 5 (HSAN5) [MIM:608654]: A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self- mutilation. The autonomic involvement is variable. {ECO:0000269PubMed:14976160, ECO:0000269PubMed:22302274}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005102	receptor binding
GO:0005163	nerve growth factor receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0006954	inflammatory response
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0007422	peripheral nervous system development
GO:0007613	memory
GO:0007623	circadian rhythm
GO:0008284	positive regulation of cell proliferation
GO:0008344	adult locomotory behavior
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0009314	response to radiation
GO:0009612	response to mechanical stimulus
GO:0010033	response to organic substance
GO:0010193	response to ozone
GO:0010628	positive regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0014042	positive regulation of neuron maturation
GO:0014070	response to organic cyclic compound
GO:0019233	sensory perception of pain
GO:0030307	positive regulation of cell growth
GO:0031175	neuron projection development
GO:0031954	positive regulation of protein autophosphorylation
GO:0032455	nerve growth factor processing
GO:0032496	response to lipopolysaccharide
GO:0035094	response to nicotine
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045773	positive regulation of axon extension
GO:0045786	negative regulation of cell cycle
GO:0046928	regulation of neurotransmitter secretion
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048812	neuron projection morphogenesis
GO:0050770	regulation of axonogenesis
GO:0050772	positive regulation of axonogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384	response to glucocorticoid
GO:0051388	positive regulation of nerve growth factor receptor signaling pathway
GO:0051402	neuron apoptotic process
GO:0051602	response to electrical stimulus
GO:0097190	apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000648	positive regulation of stem cell proliferation
GO:2000675	negative regulation of type B pancreatic cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005768	endosome
GO:0005796	Golgi lumen

Protein Structure and Domains

PDB ID

InterPro

IPR002072 Nerve growth factor-related
IPR020408 Nerve growth factor-like
IPR020425 Nerve growth factor, beta subunit
IPR020437 Nerve growth factor, beta subunit, mammalian
IPR029034 Cystine-knot cytokine

PFAM

PF00243

PRINTS

PR00268
PR01913
PR01925

PIRSF

PIRSF001789

SMART

SM00140

TIGRFAMs

Post-translational Modifications

Modification

Cross-References