InnateDB Protein
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IDBP-10194.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDCD6
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Protein Name
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programmed cell death 6
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Synonyms
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ALG-2; PEF1B;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000264933
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InnateDB Gene
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IDBG-409259 (PDCD6)
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Protein Structure
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Function |
Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5. {ECO:0000250, ECO:0000269PubMed:16132846, ECO:0000269PubMed:17889823, ECO:0000269PubMed:19520058, ECO:0000269PubMed:19864416, ECO:0000269PubMed:21893193}.
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Subcellular Localization |
Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Endosome. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
51
[view]
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Protein-Protein |
51
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
GO:0001525
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angiogenesis
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GO:0001938
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positive regulation of endothelial cell proliferation
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GO:0006508
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proteolysis
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GO:0006886
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intracellular protein transport
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GO:0006915
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apoptotic process
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0010595
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positive regulation of endothelial cell migration
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GO:0030948
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negative regulation of vascular endothelial growth factor receptor signaling pathway
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GO:0032007
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negative regulation of TOR signaling
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GO:0034605
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cellular response to heat
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GO:0036324
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vascular endothelial growth factor receptor-2 signaling pathway
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GO:0045766
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positive regulation of angiogenesis
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GO:0051592
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response to calcium ion
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GO:0051898
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negative regulation of protein kinase B signaling
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GO:0097190
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apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR002048
EF-hand domain
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PFAM |
PF00036
PF13202
PF13405
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PRINTS |
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PIRSF |
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SMART |
SM00054
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TIGRFAMs |
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Modification |
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SwissProt |
O75340
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PhosphoSite |
PhosphoSite-O75340
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TrEMBL |
Q86W51
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UniProt Splice Variant |
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Entrez Gene |
10016
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UniGene |
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RefSeq |
NP_037364
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HUGO |
HGNC:8765
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OMIM |
601057
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CCDS |
CCDS3854
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HPRD |
03035
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IMGT |
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EMBL |
AC010442
AC021087
AC118458
AF035606
AK315370
BC012384
BC050597
BC106706
BC110291
BT020072
CB991882
CH471235
U58773
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GenPept |
AAC27697
AAF14336
AAH12384
AAH50597
AAI06707
AAI10292
AAV38875
BAG37763
EAW50987
EAW50990
EAW50991
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