InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCL1

Summary

InnateDB Protein

IDBP-102149.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCL1

Protein Name

myeloid cell leukemia sequence 1 (BCL2-related)

Synonyms

bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; TM;

Species

Homo sapiens

Ensembl Protein

ENSP00000309973

InnateDB Gene

IDBG-102145 (MCL1)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269PubMed:10766760, ECO:0000269PubMed:16543145}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	87 [view]
Protein-Protein	82 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015266	protein channel activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding

Biological Process

GO:0001709	cell fate determination
GO:0007275	multicellular organismal development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0019725	cellular homeostasis
GO:0034097	response to cytokine
GO:0071806	protein transmembrane transport
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097194	execution phase of apoptosis
GO:1900118	negative regulation of execution phase of apoptosis
GO:2000811	negative regulation of anoikis
GO:2001020	regulation of response to DNA damage stimulus
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0097136	Bcl-2 family protein complex