InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTSK

Summary

InnateDB Protein

IDBP-102196.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSK

Protein Name

cathepsin K

Synonyms

CTS02; CTSO; CTSO1; CTSO2; PKND; PYCD;

Species

Homo sapiens

Ensembl Protein

ENSP00000271651

InnateDB Gene

IDBG-102192 (CTSK)

Protein Structure

UniProt Annotation

Function

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

Subcellular Localization

Lysosome.

Disease Associations

Pycnodysostosis (PKND) [MIM:265800]: A rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone. {ECO:0000269PubMed:10491211, ECO:0000269PubMed:10878663, ECO:0000269PubMed:8703060, ECO:0000269PubMed:9529353}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Predominantly expressed in osteoclasts (bones).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	6 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0004197	cysteine-type endopeptidase activity
GO:0005518	collagen binding
GO:0008234	cysteine-type peptidase activity
GO:0043394	proteoglycan binding

Biological Process

GO:0001957	intramembranous ossification
GO:0002224	toll-like receptor signaling pathway
GO:0006508	proteolysis
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0051603	proteolysis involved in cellular protein catabolic process