InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGP

Summary

InnateDB Protein

IDBP-10221.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGP

Protein Name

phosphoglycolate phosphatase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000330918

InnateDB Gene

IDBG-10219 (PGP)

Protein Structure

UniProt Annotation

Function

Phosphatase with broad substrate specificity. Has high phosphatase activity toward ADP, ATP, GDP, GTP and p- nitrophenylphosphate. Has tyrosine-protein phosphatase activity (in vitro). Has very low activity with pyridoxal 5'-phosphate (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in all tissues including red cells, lymphocytes and cultured fibroblasts (at protein level). The highest activities occur in skeletal muscle and cardiac muscle. {ECO:0000269PubMed:215071}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004725	protein tyrosine phosphatase activity
GO:0008967	phosphoglycolate phosphatase activity
GO:0016791	phosphatase activity
GO:0098519	nucleotide phosphatase activity, acting on free nucleotides