InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POGZ

Summary

InnateDB Protein

IDBP-102381.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POGZ

Protein Name

pogo transposable element with ZNF domain

Synonyms

ZNF280E; ZNF635; ZNF635m;

Species

Homo sapiens

Ensembl Protein

ENSP00000357856

InnateDB Gene

IDBG-102373 (POGZ)

Protein Structure

UniProt Annotation

Function

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. {ECO:0000269PubMed:20562864}.

Subcellular Localization

Nucleus. Chromosome. Cytoplasm. Note=According to some authors, it is not localized to mitotic chromatin (PubMed:19244240). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3). {ECO:0000269PubMed:19244240}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007064	mitotic sister chromatid cohesion
GO:0051382	kinetochore assembly

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR004875 DDE superfamily endonuclease, CENP-B-like
IPR006600 HTH CenpB-type DNA-binding domain
IPR007087 Zinc finger, C2H2
IPR009057 Homeodomain-like
IPR015880 Zinc finger, C2H2-like

PFAM

PF03184
PF03221
PF00096

PRINTS

PIRSF

SMART

SM00674
SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7Z3K3