Version 5.4
Homo sapiens Protein: SPRR1B
Summary
InnateDB Protein IDBP-102594.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRR1B
Protein Name small proline-rich protein 1B
Synonyms CORNIFIN; GADD33; SPRR1;
Species Homo sapiens
Ensembl Protein ENSP00000306461
InnateDB Gene IDBG-102592 (SPRR1B)
Protein Structure
UniProt Annotation
Function Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0030674 protein binding, bridging
Biological Process
GO:0008544 epidermis development
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003302 Cornifin (SPRR1)
PFAM PF02389
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22528
PhosphoSite PhosphoSite-P22528
TrEMBL E7ETD7
UniProt Splice Variant
Entrez Gene 6699
UniGene
RefSeq NP_003116
HUGO HGNC:11260
OMIM 182266
CCDS CCDS30863
HPRD 01648
IMGT
EMBL AK312191 AL356867 AY787223 BC056240 M19888 M21300 M21301 M84757
GenPept AAA36636 AAA36637 AAA36638 AAA36643 AAH56240 AAV40826 BAG35124 CAI19805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca