InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S100A6

Summary

InnateDB Protein

IDBP-102683.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100A6

Protein Name

S100 calcium binding protein A6

Synonyms

2A9; 5B10; CABP; CACY; PRA;

Species

Homo sapiens

Ensembl Protein

ENSP00000357709

InnateDB Gene

IDBG-102681 (S100A6)

Protein Structure

UniProt Annotation

Function

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. {ECO:0000269PubMed:22399290}.

Subcellular Localization

Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005523	tropomyosin binding
GO:0008270	zinc ion binding
GO:0015075	ion transmembrane transporter activity
GO:0042803	protein homodimerization activity
GO:0044548	S100 protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0034220	ion transmembrane transport
GO:0048146	positive regulation of fibroblast proliferation

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome