InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S100A13

Summary

InnateDB Protein

IDBP-102738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100A13

Protein Name

S100 calcium binding protein A13

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000344822

InnateDB Gene

IDBG-102736 (S100A13)

Protein Structure

UniProt Annotation

Function

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Secreted. Note=Secretion is mediated by exposure to stress and requires copper ions.

Disease Associations

Tissue Specificity

Expressed in heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0017134	fibroblast growth factor binding
GO:0042803	protein homodimerization activity
GO:0050786	RAGE receptor binding

Biological Process

GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043303	mast cell degranulation
GO:0050663	cytokine secretion
GO:0050703	interleukin-1 alpha secretion

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0042629	mast cell granule
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome