InnateDB Protein
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IDBP-102805.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CRTC2
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Protein Name
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CREB regulated transcription coactivator 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357622
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InnateDB Gene
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IDBG-102803 (CRTC2)
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Protein Structure
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Function |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269PubMed:14506290, ECO:0000269PubMed:14536081, ECO:0000269PubMed:15454081, ECO:0000269PubMed:16809310, ECO:0000269PubMed:16817901, ECO:0000269PubMed:16980408, ECO:0000269PubMed:17210223}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
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Disease Associations |
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Tissue Specificity |
Most abundantly expressed in the thymus. Present in both B and T-lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas. {ECO:0000269PubMed:14536081, ECO:0000269PubMed:15454081, ECO:0000269PubMed:16980408}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0008140
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cAMP response element binding protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q53ET0
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PhosphoSite |
PhosphoSite-Q53ET0
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TrEMBL |
Q8WZ18
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UniProt Splice Variant |
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Entrez Gene |
200186
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UniGene |
Hs.610004
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RefSeq |
NP_859066
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HUGO |
HGNC:27301
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OMIM |
608972
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CCDS |
CCDS30875
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HPRD |
12347
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IMGT |
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EMBL |
AF289574
AK223559
AL358472
AY360172
BC028886
BC053562
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GenPept |
AAH28886
AAH53562
AAL55758
AAQ98857
BAD97279
CAI14017
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