InnateDB Protein
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IDBP-102827.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CREB3L4
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Protein Name
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cAMP responsive element binding protein 3-like 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357596
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InnateDB Gene
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IDBG-102825 (CREB3L4)
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Protein Structure
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Function |
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=May also be located in Golgi apparatus.Processed cyclic AMP-responsive element- binding protein 3-like protein 4: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus. {ECO:0000269PubMed:11830526, ECO:0000269PubMed:12111373, ECO:0000269PubMed:17270658}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000977
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RNA polymerase II regulatory region sequence-specific DNA binding
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GO:0001228
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RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004827
Basic-leucine zipper domain
IPR008917
Transcription factor, Skn-1-like, DNA-binding domain
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PFAM |
PF00170
PF07716
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PRINTS |
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PIRSF |
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SMART |
SM00338
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TEY5
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PhosphoSite |
PhosphoSite-Q8TEY5
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TrEMBL |
B4DMZ9
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UniProt Splice Variant |
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Entrez Gene |
148327
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UniGene |
Hs.372924
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RefSeq |
NP_570968
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HUGO |
HGNC:18854
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OMIM |
607138
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CCDS |
CCDS1056
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HPRD |
06323
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IMGT |
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EMBL |
AB052778
AB052781
AF394167
AF468007
AK297703
AK304665
AL358472
AY049977
BC038962
CH471121
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GenPept |
AAH38962
AAL13157
AAL76113
AAO33070
BAC45035
BAC45224
BAG60061
BAG65440
CAI14026
CAI14027
EAW53251
EAW53253
EAW53254
EAW53256
EAW53257
EAW53258
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