InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP8B2

Summary

InnateDB Protein

IDBP-102936.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP8B2

Protein Name

ATPase, class I, type 8B, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357475

InnateDB Gene

IDBG-102932 (ATP8B2)

Protein Structure

UniProt Annotation

Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein. Cell membrane. Note=TMEM30A, but not TMEM30B, is required for its export from ER to the plasma membrane.

Disease Associations

Tissue Specificity

Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus. {ECO:0000269PubMed:12880872}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004012	phospholipid-translocating ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006812	cation transport
GO:0015914	phospholipid transport
GO:0034220	ion transmembrane transport
GO:0045332	phospholipid translocation
GO:0055085	transmembrane transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR006539 Cation-transporting P-type ATPase, subfamily IV
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P98198