InnateDB Protein
|
IDBP-102942.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
ATP8B2
|
Protein Name
|
ATPase, class I, type 8B, member 2
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000357472
|
InnateDB Gene
|
IDBG-102932 (ATP8B2)
|
Protein Structure
|
|
Function |
Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). {ECO:0000305}.
|
Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein. Cell membrane. Note=TMEM30A, but not TMEM30B, is required for its export from ER to the plasma membrane.
|
Disease Associations |
|
Tissue Specificity |
Isoform 3 is ubiquitous, with highest expression in aorta, cerebellum and uterus. {ECO:0000269PubMed:12880872}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
|
Protein-Protein |
4
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR008250
P-type ATPase, A domain
|
PFAM |
PF00122
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P98198
|
PhosphoSite |
PhosphoSite-P98198
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
57198
|
UniGene |
Hs.435700
|
RefSeq |
NP_001005855
|
HUGO |
HGNC:13534
|
OMIM |
605867
|
CCDS |
CCDS41405
|
HPRD |
05794
|
IMGT |
|
EMBL |
AB032963
AK054886
AK304806
AL137537
AL162591
AY302537
BC007837
BC030288
BC069264
CH471121
|
GenPept |
AAH07837
AAH30288
AAH69264
AAQ19027
BAA86451
BAB70822
BAG65556
CAB70799
CAH72858
EAW53205
|
|
|