Version 5.4
| Homo sapiens Protein: SHC1 | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||||
| InnateDB Protein | IDBP-103015.7 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | SHC1 | ||||||||||||||||||||||
| Protein Name | SHC (Src homology 2 domain containing) transforming protein 1 | ||||||||||||||||||||||
| Synonyms | SHC; SHCA; | ||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||
| Ensembl Protein | ENSP00000357434 | ||||||||||||||||||||||
| InnateDB Gene | IDBG-103007 (SHC1) | ||||||||||||||||||||||
| Protein Structure |
|
||||||||||||||||||||||
| UniProt Annotation | |||||||||||||||||||||||
| Function | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis. {ECO:0000250, ECO:0000269PubMed:14665640}. | ||||||||||||||||||||||
| Subcellular Localization | Cytoplasm.Isoform p46Shc: Mitochondrion matrix {ECO:0000269PubMed:14573619}. Note=Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.Isoform p66Shc: Mitochondrion {ECO:0000250}. Note=In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation. {ECO:0000250}. | ||||||||||||||||||||||
| Disease Associations | |||||||||||||||||||||||
| Tissue Specificity | Widely expressed. Expressed in neural stem cells but absent in mature neurons. | ||||||||||||||||||||||
| Comments | |||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 311 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||||
| Protein Structure and Domains | |||||||||||||||||||||||
| PDB ID | |||||||||||||||||||||||
| InterPro |
IPR000980
SH2 domain IPR006019 Phosphotyrosine interaction domain, Shc-like IPR006020 PTB/PI domain |
||||||||||||||||||||||
| PFAM |
PF00017
PF14633 PF00640 PF14719 |
||||||||||||||||||||||
| PRINTS |
PR00401
PR00629 |
||||||||||||||||||||||
| PIRSF | |||||||||||||||||||||||
| SMART |
SM00252
SM00462 |
||||||||||||||||||||||
| TIGRFAMs | |||||||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||||||
| Modification | |||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| PhosphoSite | PhosphoSite-P29353 | ||||||||||||||||||||||
| TrEMBL | X6R6D0 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 6464 | ||||||||||||||||||||||
| UniGene | Hs.743646 | ||||||||||||||||||||||
| RefSeq | |||||||||||||||||||||||
| HUGO | HGNC:10840 | ||||||||||||||||||||||
| OMIM | 600560 | ||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||
| HPRD | 02780 | ||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| EMBL | AL451085 | ||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||