InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EFNA1

Summary

InnateDB Protein

IDBP-103099.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNA1

Protein Name

ephrin-A1

Synonyms

B61; ECKLG; EFL1; EPLG1; LERK-1; LERK1; TNFAIP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000357392

InnateDB Gene

IDBG-103097 (EFNA1)

Protein Structure

UniProt Annotation

Function

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269PubMed:17332925, ECO:0000269PubMed:18794797}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:18794797}.Ephrin-A1, secreted form: Secreted.

Disease Associations

Tissue Specificity

Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). {ECO:0000269PubMed:17332925}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0003180	aortic valve morphogenesis
GO:0003183	mitral valve morphogenesis
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0014028	notochord formation
GO:0016477	cell migration
GO:0030182	neuron differentiation
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0034446	substrate adhesion-dependent cell spreading
GO:0043535	regulation of blood vessel endothelial cell migration
GO:0045765	regulation of angiogenesis
GO:0048013	ephrin receptor signaling pathway
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050770	regulation of axonogenesis
GO:0061002	negative regulation of dendritic spine morphogenesis

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0046658	anchored component of plasma membrane
GO:0070062	extracellular vesicular exosome