InnateDB Protein
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IDBP-103101.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EFNA1
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Protein Name
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ephrin-A1
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Synonyms
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B61; ECKLG; EFL1; EPLG1; LERK-1; LERK1; TNFAIP4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357391
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InnateDB Gene
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IDBG-103097 (EFNA1)
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Protein Structure
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Function |
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269PubMed:17332925, ECO:0000269PubMed:18794797}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:18794797}.Ephrin-A1, secreted form: Secreted.
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Disease Associations |
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Tissue Specificity |
Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level). {ECO:0000269PubMed:17332925}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0001525
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angiogenesis
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GO:0003180
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aortic valve morphogenesis
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GO:0003183
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mitral valve morphogenesis
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GO:0003199
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endocardial cushion to mesenchymal transition involved in heart valve formation
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GO:0007267
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cell-cell signaling
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GO:0007411
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axon guidance
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GO:0010719
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negative regulation of epithelial to mesenchymal transition
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GO:0016477
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cell migration
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GO:0033628
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regulation of cell adhesion mediated by integrin
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GO:0034446
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substrate adhesion-dependent cell spreading
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GO:0048013
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ephrin receptor signaling pathway
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GO:0050730
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regulation of peptidyl-tyrosine phosphorylation
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GO:0050731
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positive regulation of peptidyl-tyrosine phosphorylation
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GO:0061002
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negative regulation of dendritic spine morphogenesis
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Cellular Component |
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PDB ID |
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InterPro |
IPR001799
Ephrin
IPR008972
Cupredoxin
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PFAM |
PF00812
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PRINTS |
PR01347
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P20827
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PhosphoSite |
PhosphoSite-P20827
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1942
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UniGene |
Hs.516664
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RefSeq |
NP_872626
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HUGO |
HGNC:3221
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OMIM |
191164
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CCDS |
CCDS1092
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HPRD |
01858
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IMGT |
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EMBL |
AL691442
BC032698
BC095432
CH471121
CR457416
M57730
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GenPept |
AAA58388
AAH32698
AAH95432
CAG33697
CAI15319
CAI15320
EAW53131
EAW53132
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