InnateDB Protein
|
IDBP-103320.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SYT11
|
Protein Name
|
synaptotagmin XI
|
Synonyms
|
SYT12; sytXI;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000357307
|
InnateDB Gene
|
IDBG-103318 (SYT11)
|
Protein Structure
|
|
Function |
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. {ECO:0000250}.
|
Subcellular Localization |
Membrane {ECO:0000269PubMed:12925569}; Single-pass membrane protein {ECO:0000269PubMed:12925569}. Cell junction, synapse {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core of the Lewy bodies in the brain of sporadic Parkinson disease patients.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
8
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000008
C2 domain
IPR001565
Synaptotagmin
|
PFAM |
PF00168
|
PRINTS |
PR00360
PR00399
|
PIRSF |
|
SMART |
SM00239
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9BT88
|
PhosphoSite |
PhosphoSite-Q9BT88
|
TrEMBL |
B4DK40
|
UniProt Splice Variant |
|
Entrez Gene |
23208
|
UniGene |
Hs.627498
|
RefSeq |
NP_689493
|
HUGO |
HGNC:19239
|
OMIM |
608741
|
CCDS |
CCDS1122
|
HPRD |
12289
|
IMGT |
|
EMBL |
AK027540
AK074931
AK296378
AL139128
BC004291
BC013690
BC039205
CR749792
D38522
|
GenPept |
AAH04291
AAH13690
AAH39205
BAA07527
BAB55186
BAC11300
BAG59052
CAH18653
CAH69948
|
|
|