InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMG5

Summary

InnateDB Protein

IDBP-103449.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMG5

Protein Name

smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)

Synonyms

EST1B; LPTS-RP1; LPTSRP1; SMG-5;

Species

Homo sapiens

Ensembl Protein

ENSP00000355261

InnateDB Gene

IDBG-103447 (SMG5)

Protein Structure

UniProt Annotation

Function

Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269PubMed:17053788}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14636577}. Nucleus {ECO:0000269PubMed:14636577}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:12699629, ECO:0000269PubMed:14636577}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006406	mRNA export from nucleus
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0035303	regulation of dephosphorylation