InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTRK1

Summary

InnateDB Protein

IDBP-103638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTRK1

Protein Name

neurotrophic tyrosine kinase, receptor, type 1

Synonyms

MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA;

Species

Homo sapiens

Ensembl Protein

ENSP00000351486

InnateDB Gene

IDBG-103632 (NTRK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	62 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005030	neurotrophin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0038179	neurotrophin signaling pathway

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR020461 Tyrosine-protein kinase, neurotrophic receptor, type 1
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR020777 Tyrosine-protein kinase, neurotrophic receptor

PFAM

PF01463
PF00069
PF07714

PRINTS

PR00109
PR01940
PR01939

PIRSF

SMART

SM00082
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt