InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIRREL

Summary

InnateDB Protein

IDBP-103728.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIRREL

Protein Name

kin of IRRE like (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352138

InnateDB Gene

IDBG-103722 (KIRREL)

Protein Structure

UniProt Annotation

Function

Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm.

Disease Associations

Tissue Specificity

Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. {ECO:0000269PubMed:11416156}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017022	myosin binding

Biological Process

GO:0001933	negative regulation of protein phosphorylation
GO:0007588	excretion
GO:0016337	single organismal cell-cell adhesion
GO:0030838	positive regulation of actin filament polymerization

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016021	integral component of membrane
GO:0031253	cell projection membrane
GO:0043198	dendritic shaft
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07679
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96J84