InnateDB Protein
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IDBP-104026.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PEX19
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Protein Name
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peroxisomal biogenesis factor 19
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Synonyms
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D1S2223E; HK33; PBD12A; PMP1; PMPI; PXF; PXMP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357051
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InnateDB Gene
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IDBG-104024 (PEX19)
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Protein Structure
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Function |
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000269PubMed:10051604, ECO:0000269PubMed:10704444, ECO:0000269PubMed:11259404, ECO:0000269PubMed:11883941, ECO:0000269PubMed:14709540, ECO:0000269PubMed:15007061}.
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Subcellular Localization |
Cytoplasm. Peroxisome membrane; Lipid- anchor; Cytoplasmic side. Note=Mainly cytoplasmic. Some fraction membrane-associated to the outer surface of peroxisomes.
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Disease Associations |
Peroxisome biogenesis disorder complementation group 14 (PBD-CG14) [MIM:614886]: A peroxisomal disorder arising from a failure of protein import into the peroxisomal membrane or matrix. The peroxisome biogenesis disorders (PBD group) are genetically heterogeneous with at least 14 distinct genetic groups as concluded from complementation studies. Include disorders are: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). ZWS, NALD and IRD are distinct from RCDP and constitute a clinical continuum of overlapping phenotypes known as the Zellweger spectrum (PBD-ZSS). {ECO:0000269PubMed:20683989}. Note=The disease is caused by mutations affecting the gene represented in this entry.Peroxisome biogenesis disorder 12A (PBD12A) [MIM:614886]: A fatal peroxisome biogenesis disorder belonging to the Zellweger disease spectrum and clinically characterized by severe neurologic dysfunction with profound psychomotor retardation, severe hypotonia and neonatal seizures, craniofacial abnormalities, liver dysfunction, and biochemically by the absence of peroxisomes. Additional features include cardiovascular and skeletal defects, renal cysts, ocular abnormalities, and hearing impairment. Most severely affected individuals with the classic form of the disease (classic Zellweger syndrome) die within the first year of life. {ECO:0000269PubMed:10051604}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitously expressed. Isoform 1 is strongly predominant in all tissues except in utero where isoform 2 is the main form. {ECO:0000269PubMed:9339377}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
56
[view]
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Protein-Protein |
53
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006708
Pex19 protein
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PFAM |
PF04614
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P40855
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PhosphoSite |
PhosphoSite-P40855
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TrEMBL |
B7Z6I5
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UniProt Splice Variant |
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Entrez Gene |
5824
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UniGene |
Hs.609165
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RefSeq |
NP_002848
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HUGO |
HGNC:9713
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OMIM |
600279
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CCDS |
CCDS1201
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HPRD |
02610
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IMGT |
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EMBL |
AB018541
AB062286
AK300368
AL513282
BC000496
BT006879
CH471121
X75535
Y09048
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GenPept |
AAH00496
AAP35525
BAA76291
BAB93469
BAH13271
CAA53225
CAA70257
CAI12457
EAW52727
EAW52728
EAW52729
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