Version 5.4
Homo sapiens Protein: CD244
Summary
InnateDB Protein IDBP-104116.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD244
Protein Name CD244 molecule, natural killer cell receptor 2B4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357013
InnateDB Gene IDBG-104114 (CD244)
Protein Structure
UniProt Annotation
Function Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family. {ECO:0000269PubMed:10359122}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils. {ECO:0000269PubMed:10556801}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007110 Immunoglobulin-like domain
IPR024303 Natural killer cell receptor 2B4 immunoglobulin domain
PFAM PF11465
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BZW8
PhosphoSite PhosphoSite-Q9BZW8
TrEMBL
UniProt Splice Variant
Entrez Gene 51744
UniGene Hs.157872
RefSeq NP_057466
HUGO HGNC:18171
OMIM 605554
CCDS CCDS1210
HPRD 16121
IMGT
EMBL AF105261 AF107761 AF117711 AF145782 AF242540 AF363452 AJ245375 AJ245376 AJ245377 AL354714 BC028073 BC053985 CH471121
GenPept AAD32538 AAD37838 AAD38951 AAF28833 AAH28073 AAH53985 AAK00233 AAK50015 CAC00647 CAC00648 CAC00649 CAH72353 CAH72354 CAH72355 EAW52691 EAW52692 EAW52693

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca