InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: USF1

Summary

InnateDB Protein

IDBP-104156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

USF1

Protein Name

upstream transcription factor 1

Synonyms

bHLHb11; FCHL; FCHL1; HYPLIP1; MLTF; MLTFI; UEF;

Species

Homo sapiens

Ensembl Protein

ENSP00000356999

InnateDB Gene

IDBG-104152 (USF1)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.

Subcellular Localization

Nucleus.

Disease Associations

Hyperlipidemia combined 1 (HYPLIP1) [MIM:602491]: A disorder characterized by a variable pattern of elevated levels of serum total cholesterol, triglycerides or both. It is observed in a percentage of individuals with premature coronary heart disease. {ECO:0000269PubMed:14991056}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	50 [view]
Protein-DNA	15 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity
GO:0042826	histone deacetylase binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose
GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0001666	response to hypoxia
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0009411	response to UV
GO:0019086	late viral transcription
GO:0032869	cellular response to insulin stimulus
GO:0042593	glucose homeostasis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045990	carbon catabolite regulation of transcription
GO:0051918	negative regulation of fibrinolysis
GO:0055088	lipid homeostasis