Version 5.4
Homo sapiens Protein: MCAT
Summary
InnateDB Protein IDBP-10432.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MCAT
Protein Name malonyl CoA:ACP acyltransferase (mitochondrial)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000331306
InnateDB Gene IDBG-10428 (MCAT)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias. {ECO:0000269PubMed:12882974}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:12882974}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity
GO:0016740 transferase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR014043 Acyl transferase
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
PFAM PF00698
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IVS2
PhosphoSite PhosphoSite-Q8IVS2
TrEMBL
UniProt Splice Variant
Entrez Gene 27349
UniGene Hs.349111
RefSeq NP_055322
HUGO HGNC:29622
OMIM 614479
CCDS CCDS14045
HPRD 14786
IMGT
EMBL AK314059 AL022237 AL359401 AL359403 BC030985 BC042195 CH471138
GenPept AAH30985 AAH42195 BAG36765 CAA18261 CAB94789 CAB94790 CAQ07851 EAW73286

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca