Version 5.4
Homo sapiens Protein: DPT
Summary
InnateDB Protein IDBP-104638.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPT
Protein Name dermatopontin
Synonyms TRAMP;
Species Homo sapiens
Ensembl Protein ENSP00000356791
InnateDB Gene IDBG-104636 (DPT)
Protein Structure
UniProt Annotation
Function Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts. {ECO:0000269PubMed:10233760, ECO:0000269PubMed:8104875}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
GO:0008285 negative regulation of cell proliferation
GO:0030199 collagen fibril organization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q07507
PhosphoSite PhosphoSite-Q07507
TrEMBL
UniProt Splice Variant
Entrez Gene 1805
UniGene Hs.80552
RefSeq NP_001928
HUGO HGNC:3011
OMIM 125597
CCDS CCDS1275
HPRD 00510
IMGT
EMBL AK292596 AL049798 BC033736 CH471067 Z22865
GenPept AAH33736 BAF85285 CAA80487 CAB46693 EAW90830

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca