InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SELP

Summary

InnateDB Protein

IDBP-104679.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SELP

Protein Name

selectin P (granule membrane protein 140kDa, antigen CD62)

Synonyms

CD62; CD62P; GMP140; GRMP; LECAM3; PADGEM; PSEL;

Species

Homo sapiens

Ensembl Protein

ENSP00000263686

InnateDB Gene

IDBG-104675 (SELP)

Protein Structure

UniProt Annotation

Function

Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. {ECO:0000269PubMed:7585950}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001530	lipopolysaccharide binding
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0033691	sialic acid binding
GO:0042806	fucose binding
GO:0043208	glycosphingolipid binding
GO:0048306	calcium-dependent protein binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0002576	platelet degranulation
GO:0002687	positive regulation of leukocyte migration
GO:0006954	inflammatory response
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007596	blood coagulation
GO:0010572	positive regulation of platelet activation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030168	platelet activation
GO:0032496	response to lipopolysaccharide
GO:0033623	regulation of integrin activation
GO:0050829	defense response to Gram-negative bacterium
GO:0050900	leukocyte migration
GO:0050901	leukocyte tethering or rolling

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031088	platelet dense granule membrane
GO:0031092	platelet alpha granule membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR002396 Selectin superfamily
IPR016187 C-type lectin fold

PFAM

PF00084
PF00008
PF00059

PRINTS

PR00343

PIRSF

SMART

SM00032
SM00181
SM00034

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt