Version 5.4
Homo sapiens Protein: FAM20B
Summary
InnateDB Protein IDBP-105089.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM20B
Protein Name family with sequence similarity 20, member B
Synonyms gxk1;
Species Homo sapiens
Ensembl Protein ENSP00000263733
InnateDB Gene IDBG-105087 (FAM20B)
Protein Structure
UniProt Annotation
Function Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1- O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. {ECO:0000269PubMed:19473117}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:19473117}; Single-pass type II membrane protein {ECO:0000269PubMed:19473117}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:15676076}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0016310 phosphorylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR009581 Domain of unknown function DUF1193
PFAM PF06702
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75063
PhosphoSite PhosphoSite-O75063
TrEMBL X6RH03
UniProt Splice Variant
Entrez Gene 9917
UniGene Hs.740494
RefSeq NP_055679
HUGO HGNC:23017
OMIM 611063
CCDS CCDS1328
HPRD 13297
IMGT
EMBL AB007944 AB480690 AK289989 AL139132 BC046441 BC051794 CH471067
GenPept AAH46441 AAH51794 BAA32320 BAF82678 BAH79819 CAH70923 CAH70924 EAW91034 EAW91035 EAW91036

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca