InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LHX4

Summary

InnateDB Protein

IDBP-105171.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LHX4

Protein Name

LIM homeobox 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263726

InnateDB Gene

IDBG-105169 (LHX4)

Protein Structure

UniProt Annotation

Function

May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Pituitary hormone deficiency, combined, 4 (CPHD4) [MIM:262700]: Combined pituitary hormone deficiency is defined as the impaired production of growth hormone and one or more of the other five anterior pituitary hormones. CPHD4 is characterized by complete or partial deficiencies of growth hormone, thyroid- stimulating hormone, luteinizing hormone, follicle stimulating hormone and adrenocorticotropic hormone. Clinical features include short stature, cerebellar defects, and small sella turcica. {ECO:0000269PubMed:17527005, ECO:0000269PubMed:18073311}. Note=The disease is caused by mutations affecting the gene represented in this entry.Note=A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1. {ECO:0000269PubMed:11567216}.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001890	placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008045	motor neuron axon guidance
GO:0009887	organ morphogenesis
GO:0021526	medial motor column neuron differentiation
GO:0043066	negative regulation of apoptotic process