InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TSEN15

Summary

InnateDB Protein

IDBP-105347.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TSEN15

Protein Name

tRNA splicing endonuclease 15 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355299

InnateDB Gene

IDBG-105345 (TSEN15)

Protein Structure

UniProt Annotation

Function

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269PubMed:15109492}.

Subcellular Localization

Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in testis and uterus. {ECO:0000269PubMed:11318611}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000213	tRNA-intron endonuclease activity

Biological Process

GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397	mRNA processing
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic