InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATP6V0C

Summary

InnateDB Protein

IDBP-10563.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V0C

Protein Name

ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

Synonyms

ATP6C; ATP6L; ATPL; VATL; Vma3; VPPC;

Species

Homo sapiens

Ensembl Protein

ENSP00000329757

InnateDB Gene

IDBG-10561 (ATP6V0C)

Protein Structure

UniProt Annotation

Function

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Vacuole membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0031625	ubiquitin protein ligase binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0016032	viral process
GO:0030177	positive regulation of Wnt signaling pathway
GO:0033572	transferrin transport
GO:0051701	interaction with host
GO:0055085	transmembrane transport
GO:0090382	phagosome maturation

Cellular Component

GO:0005765	lysosomal membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0030670	phagocytic vesicle membrane
GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0070062	extracellular vesicular exosome