InnateDB Protein
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IDBP-105651.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ZNF281
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Protein Name
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zinc finger protein 281
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Synonyms
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ZBP-99; ZNP-99;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000294740
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InnateDB Gene
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IDBG-105649 (ZNF281)
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Protein Structure
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Function |
Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs (By similarity). Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G- rich box in the enhancer region of these genes. {ECO:0000250, ECO:0000269PubMed:10448078, ECO:0000269PubMed:12771217}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10448078}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
IPR015880
Zinc finger, C2H2-like
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
SM00355
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y2X9
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PhosphoSite |
PhosphoSite-Q9Y2X9
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TrEMBL |
B3KMX4
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UniProt Splice Variant |
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Entrez Gene |
23528
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UniGene |
Hs.735801
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RefSeq |
NP_036614
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HUGO |
HGNC:13075
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OMIM |
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CCDS |
CCDS1402
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HPRD |
11702
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IMGT |
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EMBL |
AC104461
AF125158
AJ132591
AJ132592
AK022916
AK022921
BC051905
BC060820
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GenPept |
AAD21084
AAH51905
AAH60820
BAG51134
BAG51136
CAB70967
CAB70968
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