Version 5.4
Homo sapiens Protein: TNNI1
Summary
InnateDB Protein IDBP-105765.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNI1
Protein Name troponin I type 1 (skeletal, slow)
Synonyms SSTNI; TNN1;
Species Homo sapiens
Ensembl Protein ENSP00000356281
InnateDB Gene IDBG-105757 (TNNI1)
Protein Structure
UniProt Annotation
Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Subcellular Localization
Disease Associations
Tissue Specificity Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes. {ECO:0000269PubMed:2365354, ECO:0000269PubMed:8144655}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0046872 metal ion binding
Biological Process
GO:0006942 regulation of striated muscle contraction
GO:0030049 muscle filament sliding
Cellular Component
GO:0005829 cytosol
GO:0005861 troponin complex
Protein Structure and Domains
PDB ID
InterPro IPR001978 Troponin
PFAM PF00992
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P19237
PhosphoSite PhosphoSite-P19237
TrEMBL G3V4F8
UniProt Splice Variant
Entrez Gene 7135
UniGene Hs.624052
RefSeq
HUGO HGNC:11945
OMIM 191042
CCDS CCDS1411
HPRD 01842
IMGT
EMBL AC096677 AJ315823 AK223588 AK311896 AL831820 AL831975 BC012600 BC012601 BX510903 CH471067 CR450301 CR541996 CR542030 J04760 L21906 L21908 L21909 L21910
GenPept AAA61228 AAC14461 AAH12600 AAH12601 BAD97308 BAG34837 CAC44240 CAD38534 CAD91135 CAG29297 CAG46793 CAG46827 CAH56221 EAW91366 EAW91367 EAW91368

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca