InnateDB Protein
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IDBP-105793.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IPO9
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Protein Name
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importin 9
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000354742
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InnateDB Gene
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IDBG-105791 (IPO9)
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Protein Structure
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Function |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6. {ECO:0000250, ECO:0000269PubMed:11823430}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
32
[view]
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Protein-Protein |
32
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001494
Importin-beta, N-terminal domain
IPR016024
Armadillo-type fold
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PFAM |
PF03810
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PRINTS |
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PIRSF |
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SMART |
SM00913
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TIGRFAMs |
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Modification |
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SwissProt |
Q96P70
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PhosphoSite |
PhosphoSite-Q96P70
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55705
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UniGene |
Hs.618901
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RefSeq |
NP_060555
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HUGO |
HGNC:19425
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OMIM |
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CCDS |
CCDS1415
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HPRD |
17154
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IMGT |
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EMBL |
AB033018
AF161391
AF410465
AK001264
AK027532
AK074740
AK094603
AL645504
AL834323
BC003604
CH471067
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GenPept |
AAF28951
AAH03604
AAL01416
BAA86506
BAA91588
BAB55181
BAC04383
BAC11173
CAD38991
CAI17015
EAW91376
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