InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMM17A

Summary

InnateDB Protein

IDBP-105804.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMM17A

Protein Name

translocase of inner mitochondrial membrane 17 homolog A (yeast)

Synonyms

TIM17; TIM17A;

Species

Homo sapiens

Ensembl Protein

ENSP00000356256

InnateDB Gene

IDBG-105802 (TIMM17A)

Protein Structure

UniProt Annotation

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	8 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0006886	intracellular protein transport
GO:0044267	cellular protein metabolic process
GO:0071806	protein transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005744	mitochondrial inner membrane presequence translocase complex
GO:0031305	integral component of mitochondrial inner membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003397 Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24
IPR005678 Mitochondrial inner membrane translocase complex, subunit Tim17

PFAM

PF02466

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99595

PhosphoSite