InnateDB Protein
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IDBP-105845.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBE2T
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Protein Name
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ubiquitin-conjugating enzyme E2T (putative)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356243
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InnateDB Gene
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IDBG-105843 (UBE2T)
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Protein Structure
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Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. {ECO:0000269PubMed:16916645, ECO:0000269PubMed:17938197, ECO:0000269PubMed:19111657, ECO:0000269PubMed:19589784, ECO:0000269PubMed:19887602, ECO:0000269PubMed:20061386}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:17938197, ECO:0000269PubMed:19887602}. Note=Accumulates to chromatin.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
25
[view]
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Protein-Protein |
25
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NPD8
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PhosphoSite |
PhosphoSite-Q9NPD8
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TrEMBL |
A0A024R9A9
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UniProt Splice Variant |
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Entrez Gene |
29089
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UniGene |
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RefSeq |
NP_054895
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HUGO |
HGNC:25009
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OMIM |
610538
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CCDS |
CCDS1425
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HPRD |
13704
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IMGT |
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EMBL |
AB032931
AF160215
AF161499
AK000504
AL356953
AY542309
BC004152
BC019284
CH471067
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GenPept |
AAF29114
AAF67016
AAH04152
AAH19284
AAT08178
BAA91211
BAA93711
CAI15933
EAW91411
EAW91415
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