InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPFIA4

Summary

InnateDB Protein

IDBP-105917.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPFIA4

Protein Name

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295706

InnateDB Gene

IDBG-105909 (PPFIA4)

Protein Structure

UniProt Annotation

Function

May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with PTPRF at the cell surface. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed only in the heart, brain, and skeletal muscle. {ECO:0000269PubMed:9624153}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF07647
PF00536

PRINTS

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75335