InnateDB Protein
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IDBP-106056.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MDM4
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Protein Name
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Mdm4 p53 binding protein homolog (mouse)
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Synonyms
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HDMX; MDMX; MRP1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356151
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InnateDB Gene
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IDBG-106054 (MDM4)
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Protein Structure
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Function |
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269PubMed:16163388, ECO:0000269PubMed:16511572}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues tested with high levels in thymus.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
80
[view]
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Protein-Protein |
79
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001841
Zinc finger, RING-type
IPR016495
p53 negative regulator Mdm2/Mdm4
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
PIRSF006748
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
O15151
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PhosphoSite |
PhosphoSite-O15151
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
4194
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UniGene |
Hs.658187
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RefSeq |
NP_001191101
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HUGO |
HGNC:6974
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OMIM |
602704
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CCDS |
CCDS55675
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HPRD |
04082
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IMGT |
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EMBL |
AF007111
AK223228
AL512306
AY207458
AY923176
BC067299
BC105106
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GenPept |
AAB62928
AAH67299
AAI05107
AAO13494
AAY22054
BAD96948
CAI14100
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