InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: YOD1

Summary

InnateDB Protein

IDBP-106312.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YOD1

Protein Name

YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000326813

InnateDB Gene

IDBG-106308 (YOD1)

Protein Structure

UniProt Annotation

Function

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. {ECO:0000269PubMed:19818707, ECO:0000269PubMed:23827681}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:1990380	Lys48-specific deubiquitinase activity

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0035523	protein K29-linked deubiquitination
GO:0035871	protein K11-linked deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination
GO:1990167	protein K27-linked deubiquitination
GO:1990168	protein K33-linked deubiquitination