InnateDB Protein
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IDBP-106325.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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C4BPB
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Protein Name
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complement component 4 binding protein, beta
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Synonyms
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C4BP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000243611
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InnateDB Gene
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IDBG-106321 (C4BPB)
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Protein Structure
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Function |
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000436
Sushi/SCR/CCP
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PFAM |
PF00084
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PRINTS |
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PIRSF |
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SMART |
SM00032
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TIGRFAMs |
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Modification |
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SwissProt |
P20851
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PhosphoSite |
PhosphoSite-P20851
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TrEMBL |
Q5VVQ7
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UniProt Splice Variant |
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Entrez Gene |
725
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UniGene |
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RefSeq |
NP_000707
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HUGO |
HGNC:1328
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OMIM |
120831
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CCDS |
CCDS1476
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HPRD |
00404
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IMGT |
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EMBL |
AL445493
BC005378
CH471100
EF613556
L11244
L11245
M29964
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GenPept |
AAA35615
AAA35616
AAB59520
AAH05378
ABQ52216
CAH70780
CAH70781
EAW93504
EAW93506
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