InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CR1

Summary

InnateDB Protein

IDBP-106364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CR1

Protein Name

complement component (3b/4b) receptor 1 (Knops blood group)

Synonyms

C3BR; C4BR; CD35; KN;

Species

Homo sapiens

Ensembl Protein

ENSP00000356018

InnateDB Gene

IDBG-106358 (CR1)

Protein Structure

UniProt Annotation

Function

Mediates cellular binding of particles and immune complexes that have activated complement.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001851	complement component C3b binding
GO:0001855	complement component C4b binding
GO:0001861	complement component C4b receptor activity
GO:0004877	complement component C3b receptor activity

Biological Process

GO:0002430	complement receptor mediated signaling pathway
GO:0006958	complement activation, classical pathway
GO:0030449	regulation of complement activation
GO:0045087	innate immune response
GO:0045957	negative regulation of complement activation, alternative pathway
GO:0045959	negative regulation of complement activation, classical pathway
GO:1900004	negative regulation of serine-type endopeptidase activity
GO:1900005	positive regulation of serine-type endopeptidase activity