InnateDB Protein
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IDBP-106468.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SYT14
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Protein Name
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synaptotagmin XIV
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000355982
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InnateDB Gene
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IDBG-106460 (SYT14)
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Protein Structure
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Function |
May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:21835308}; Single-pass type III membrane protein {ECO:0000269PubMed:21835308}. Note=Localized in perinuclear and submembranous regions.
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Disease Associations |
Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11) [MIM:614229]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR11 is associated with psychomotor retardation. {ECO:0000269PubMed:21835308}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Highly expressed in fetal and adult brain tissue. {ECO:0000269PubMed:21835308}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000008
C2 domain
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PFAM |
PF00168
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PRINTS |
PR00360
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PIRSF |
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SMART |
SM00239
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TIGRFAMs |
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Modification |
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SwissProt |
Q8NB59
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PhosphoSite |
PhosphoSite-Q8NB59
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
255928
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UniGene |
Hs.658866
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RefSeq |
XP_005273145
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HUGO |
HGNC:23143
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OMIM |
610949
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CCDS |
CCDS58058
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HPRD |
11617
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IMGT |
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EMBL |
AB102948
AJ617623
AJ617624
AJ617625
AJ617626
AJ617627
AK091517
AL022397
AL022399
AL513263
BC144157
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GenPept |
BAC03682
BAC76809
CAE85109
CAE85110
CAE85111
CAE85112
CAE85113
CAI17884
CAI17885
CAI17886
CAI17887
CAI17888
CAI17889
CAI22770
CAI22771
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