InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TGFB2

Summary

InnateDB Protein

IDBP-106712.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFB2

Protein Name

transforming growth factor, beta 2

Synonyms

LDS4; TGF-beta2;

Species

Homo sapiens

Ensembl Protein

ENSP00000355896

InnateDB Gene

IDBG-106710 (TGFB2)

Protein Structure

UniProt Annotation

Function

TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

Subcellular Localization

Secreted.

Disease Associations

Note=A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly. Translocation t(1;7)(q41;p21) with HDAC9.Loeys-Dietz syndrome 4 (LDS4) [MIM:614816]: An aortic aneurysm syndrome with widespread systemic involvement. LDS4 is characterized by arterial tortuosity, aortic dissection, intracranial aneurysm and subarachnoid hemorrhage, hypertelorism, bifid uvula, pectus deformity, bicuspid aortic valve, arachnodactyly, scoliosis, foot deformities, dural ectasia, joint hyperflexibility, and thin skin with easy bruising and striae. {ECO:0000269PubMed:22772368}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0005102	receptor binding
GO:0005114	type II transforming growth factor beta receptor binding
GO:0005125	cytokine activity
GO:0005160	transforming growth factor beta receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001501	skeletal system development
GO:0001502	cartilage condensation
GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001654	eye development
GO:0001666	response to hypoxia
GO:0001837	epithelial to mesenchymal transition
GO:0001942	hair follicle development
GO:0001974	blood vessel remodeling
GO:0002576	platelet degranulation
GO:0003007	heart morphogenesis
GO:0006468	protein phosphorylation
GO:0007050	cell cycle arrest
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007184	SMAD protein import into nucleus
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0007435	salivary gland morphogenesis
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0008219	cell death
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008347	glial cell migration
GO:0009611	response to wounding
GO:0009790	embryo development
GO:0010002	cardioblast differentiation
GO:0010628	positive regulation of gene expression
GO:0010634	positive regulation of epithelial cell migration
GO:0010693	negative regulation of alkaline phosphatase activity
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010936	negative regulation of macrophage cytokine production
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016049	cell growth
GO:0016477	cell migration
GO:0022601	menstrual cycle phase
GO:0023014	signal transduction by phosphorylation
GO:0030097	hemopoiesis
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0030199	collagen fibril organization
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0030593	neutrophil chemotaxis
GO:0031069	hair follicle morphogenesis
GO:0032147	activation of protein kinase activity
GO:0032570	response to progesterone
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0032909	regulation of transforming growth factor beta2 production
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0040007	growth
GO:0042060	wound healing
GO:0042416	dopamine biosynthetic process
GO:0042476	odontogenesis
GO:0042493	response to drug
GO:0042637	catagen
GO:0042981	regulation of apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0045216	cell-cell junction organization
GO:0045726	positive regulation of integrin biosynthetic process
GO:0045778	positive regulation of ossification
GO:0045787	positive regulation of cell cycle
GO:0045823	positive regulation of heart contraction
GO:0048103	somatic stem cell division
GO:0048566	embryonic digestive tract development
GO:0048663	neuron fate commitment
GO:0048666	neuron development
GO:0048699	generation of neurons
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050714	positive regulation of protein secretion
GO:0050777	negative regulation of immune response
GO:0050778	positive regulation of immune response
GO:0051781	positive regulation of cell division
GO:0051795	positive regulation of catagen
GO:0051891	positive regulation of cardioblast differentiation
GO:0060038	cardiac muscle cell proliferation
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060325	face morphogenesis
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:0070237	positive regulation of activation-induced cell death of T cells
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005768	endosome
GO:0030424	axon
GO:0031012	extracellular matrix
GO:0031093	platelet alpha granule lumen
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR003940 Transforming growth factor, beta 2
IPR016319 Transforming growth factor-beta
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR01425
PR01423

PIRSF

PIRSF001787

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References