InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRP9

Summary

InnateDB Protein

IDBP-106966.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRP9

Protein Name

signal recognition particle 9kDa

Synonyms

ALURBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000355804

InnateDB Gene

IDBG-106960 (SRP9)

Protein Structure

UniProt Annotation

Function

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005047	signal recognition particle binding
GO:0008312	7S RNA binding

Biological Process

GO:0006412	translation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0044267	cellular protein metabolic process
GO:0045900	negative regulation of translational elongation

Cellular Component

GO:0005785	signal recognition particle receptor complex
GO:0005786	signal recognition particle, endoplasmic reticulum targeting
GO:0005829	cytosol
GO:0048500	signal recognition particle
GO:0070062	extracellular vesicular exosome